Article Text

Download PDFPDF
Is melatonin likely to help children with neurodevelopmental disability and chronic severe sleep problems?
  1. Caroline Willey1,
  2. Bob Phillips2
  1. 1Staff Grade Community Paediatrician, Central Manchester PCT, UK
  2. 2Associate Fellow, Centre for Evidence-based Medicine, Oxford, UK

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

A girl aged 3 years 6 months has neurofibromatosis with significant visual impairment and mild to moderate learning difficulties. She has always been difficult to settle to sleep and has frequent nocturnal wakenings.

A sleep programme with specific behavioural management techniques has been used, as have sedative medications such as trimeprazine, which caused deterioration in concentration and daytime sleepiness. Should she be tried on melatonin?

Structured clinical question

In a preschool child with visual impairment and mild to moderate learning difficulties, in whom conventional treatments have failed [patient] is melatonin [intervention] likely to improve her sleep pattern …

View Full Text


  • Bob Phillips