Article Text

Download PDFPDF
Discontinuing anticonvulsant medication in children
  1. Robert Smith,
  2. Robin Ball
  1. Consultant Paediatricians, York District Hospital, UK

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

A12 year old girl with primary generalised epilepsy comes to clinic for review. She has been seizure free for two years on sodium valproate 600 mg twice daily. Following discussion with her and her mother, an agreement is reached to withdraw the medication. You advise that the medication should be tapered off over a six week period. At this point the mother informs you that when she had her own anticonvulsant medication withdrawn, this was reduced over a six month period. She questioned whether it was appropriate to reduce the medication so quickly and requested evidence to support the recommendation, raising concerns about the possibility of a higher risk of seizure recurrence.

Structured clinical question

In a child with primary generalised epilepsy [patient] does the rate of withdrawal of anticonvulsants [intervention] affect rate of seizure recurrence or other adverse event [outcome]?

Search strategy and outcome

The Cochrane library1 search terms “epilepsy” or “anticonvulsants” yielded no relevant systematic reviews or controlled …

View Full Text


  • Bob Phillips