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Community child health, public health, and epidemiology
The meningococcus tamed?
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  1. A J Pollard,
  2. E R Moxon
  1. Oxford Vaccine Group, Department of Paediatrics, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
  1. Correspondence to:
    Dr A J Pollard, Oxford Vaccine Group, Department of Paediatrics, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK;
    andrew.pollard{at}paediatrics.ox.ac.uk

Abstract

Serogroup B Neisseria meningitidis is a frequent cause of invasive meningococcal disease, yet there are no effective vaccines suitable for routine immunisation. Limited efficacy has been shown with meningococcal outer membrane vacccines in children 4 years and older. Here we review the status of current research and consider new approaches to development of meningococcal serogroup B vaccines.

  • meningococcus
  • vaccine
  • meningitis
  • review
  • immunisation
  • Hib, Haemophilus influenzae type b
  • LPS, lipopolysaccharide
  • OMP, outer membrane protein
  • OMV, outer membrane vesicle

http://dx.doi.org/10.1136/adc.87.1.13

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    Copyright 2002 Archives of Disease in Childhood

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