Serogroup B Neisseria meningitidis is a frequent cause of invasive meningococcal disease, yet there are no effective vaccines suitable for routine immunisation. Limited efficacy has been shown with meningococcal outer membrane vacccines in children 4 years and older. Here we review the status of current research and consider new approaches to development of meningococcal serogroup B vaccines.
- Hib, Haemophilus influenzae type b
- LPS, lipopolysaccharide
- OMP, outer membrane protein
- OMV, outer membrane vesicle
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