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Procalcitonin as a diagnostic marker of meningococcal disease in children presenting with fever and a rash
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  • Published on:
    Procalcitonin as a marker of meningococcal disease
    • Enitan D Carrol, Lecturer in Paediatric Medicine
    • Other Contributors:
      • Paul Newland, F Andrew I Riordan, Alistair PJ Thomson, Nicola Curtis, C Anthony Hart

    Dear Editor

    We thank Professor Leclerc for his interest in our paper. We disagree with some of his comments, however.

    Firstly, the definition of severe meningococcal disease (MCD) is defined in the methods section as a Glasgow Meningococcal Septicaemia Prognostic Score GMSPS >= 8.[1] This is a well recognised and validated definition,[2] and one that has been used as entry criteria for randomised con...

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    Conflict of Interest:
    None declared.
  • Published on:
    Procalcitonin as a prognostic marker in children with meningococcal septic shock

    Dear Editor

    We read with interest the paper from Carrol and coworkers who have demonstrated for the first time that procalcitonin (PCT), even it cannot be presented as a gold standard (7 % of false negative), is a promising marker of meningococcal disease (MCD) in children presenting with fever and rash.[1] Carrol et al. also observed that PCT level was significantly higher (p = 0.001) in children with...

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    Conflict of Interest:
    None declared.