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Nitrous oxide and vitamin B12
  1. ISABEL SMITH
  1. Clinical Audit Department
  2. Great Ormond Street Hospital
  3. Great Ormond Street
  4. London WC1N 3JH
  5. smithi@gosh.nhs.uk

https://doi.org/10.1136/adc.85.6.510e

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    Editor,—The paper by Kanagasundaramet al 1 on the use of nitrous oxide to alleviate pain and anxiety during painful procedures fails to mention the effect of this gas on cobalamin metabolism. Nitrous oxide inactivates cob(I)alamin, the active derivative of vitamin B12 and essential cofactor for the transfer of the methyl group from …

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