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Vertebral compression fractures in acute lymphoblastic leukaemia and remodelling after treatment


Three children, aged 7–10 years, with acute lymphoblastic leukaemia presented with back pain, along with a mild kyphosis. Collapse of the vertebral bodies at multiple levels was shown on imaging. Chemotherapy resulted in pain resolution and spontaneous remodelling of the vertebrae.

  • acute lymphoblastic leukaemia
  • compression fractures
  • osteopenia
  • vertebral collapse

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Bone and joint pain may be a presenting symptom in 25% of patients with acute leukaemia,1 whereas generalised osteopenia and vertebral complications are less common.2

We report three children in whom back pain associated with vertebral compression and collapse were presenting features of childhood acute lymphoblastic leukaemia (ALL); radiological remodelling with return of function occurred with remission.

Case 1

A 7 year old boy presented with generalised joint and back pain, widespread lymphadenopathy, a kyphosis of the thoracic spine, and hepatomegaly. Haemoglobin was 71 g/l, leucocyte count 1.8 × 109, and platelet count 73 × 109.

Radiology revealed osteopenia and vertebral compression fractures throughout the thoracic and lumbar spine. Magnetic resonance imaging (MRI) showed a diffuse alteration of signal in the marrow cavities (fig1).

Figure 1

T1 weighted sagittal images of the spine showing diffuse homogeneous signal from the vertebral bone marrow cavities, indicating a diffuse pathology as the cause of the multiple compression fractures. There is no evidence of spinal cord compression.

A diagnosis of ALL (L1) was made on bone marrow aspirates. Treatment was commenced and subsequent remodelling of the bone and vertebrae was observed and documented (fig 2). A mild kyphosis persists six years after presentation.

Figure 2

Following successful treatment, the lateral radiograph of the thoracic spine has returned to normal, with remodelling and reconstitution of bony texture.

Case 2

A 9 year old girl presented with a two month history of progressive low back pain. Initial haematology was normal; however, a repeat blood count two months later revealed a haemoglobin of 99 g/l, leucocyte count of 2.6 × 109, and platelet count of 53 × 109, along with circulating blasts on peripheral blood films. Serum calcium concentration was 2.85 mmol/l (normal range 2.2–2.7 mmol/l), phosphate 1.65 mmol/l (1.2–1.65 mmol/l), magnesium 0.92 mmol/l (0.6–0.9 mmol/l), and alkaline phosphatase 177 U/l (145–420 U/l).

Clinical examination showed hepatosplenomegaly. Bone marrow aspirates confirmed ALL (L2). Radiology showed compression fractures of the vertebral bodies in the lower thoracic region. Persistently raised calcium concentrations were treated with bisphosphonate infusion. A relapse was signalled by bone pain, normal biochemistry, and osteopenic vertebrae without collapse (the latter confirming that some remodelling had occurred during remission) 16 months after completion of initial treatment.

Case 3

A 10 year old girl presented with a three month history of increasing lower back pain. Clinical examination was normal. MRI showed a diffuse homogeneous abnormal signal from the marrow cavities of the vertebral bodies with compression fractures in the lower thoracic region. Haemoglobin was 114 g/l, platelets 102 × 109, leucocyte count 1.6×109, and neutrophils 0.4 × 109. Bone marrow aspirate showed infiltration with L2 lymphoblasts.

She continues to remain pain free and in remission on treatment.


Radiological evidence of demineralisation during the course of leukaemia can be caused by disease, inactivity, steroids, or other antileukemic drugs, or to abnormalities in mineral homoeostasis.3

Spinal involvement may be a presenting feature despite normal peripheral blood counts.4 ,5

The use of MRI in the diagnosis of bone marrow disease in children is complicated by the change that takes place in the relative proportions of haematogenous and fatty marrow. In the context of bony pain with vertebral collapse, the finding of diffuse low signal in the vertebral marrow cavities is a strong indicator of a systemic disease affecting the marrow. Steroid therapy causing vertebral collapse should leave the marrow signal in other vertebrae unchanged.6

Diagnosis was delayed up to three months in all three patients. Case 2 had hypercalcaemia at presentation. Biphosphonate decreases bone pain and helps to prevent complications of progressive vertebral collapse.7

Vertebral compression fractures seldom cause neurological compromise, and they appear to remodel as the underlying disease is treated. ALL which presents with leucopenia, severe and constant pain, and a long interval between the onset of symptoms and diagnosis, carries an unfavourable outlook.8 The significance of bone involvement at diagnosis is uncertain. Heinrich et al suggested that duration of symptoms prior to diagnosis influences outcome rather than the nature of skeletal radiographic abnormalities.9


There should be a high index of suspicion in patients, particularly if there is worsening back pain with the associated radiographic findings of vertebral compression fractures and an abnormal bone marrow signal on MRI.

Antileukemic treatment usually results in rapid symptomatic relief as well as radiographic evidence of bony remodelling.