Download PDFPDF

Increased urinary leukotriene E4 during febrile attacks in the hyperimmunoglobulinaemia D and periodic fever syndrome
Compose Response

Plain text

  • No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.
Author Information
First or given name, e.g. 'Peter'.
Your last, or family, name, e.g. 'MacMoody'.
Your email address, e.g.
Your role and/or occupation, e.g. 'Orthopedic Surgeon'.
Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.
Statement of Competing Interests


  • Responses are moderated before posting and publication is at the absolute discretion of BMJ, however they are not peer-reviewed
  • Once published, you will not have the right to remove or edit your response. Removal or editing of responses is at BMJ's absolute discretion
  • If patients could recognise themselves, or anyone else could recognise a patient from your description, please obtain the patient's written consent to publication and send them to the editorial office before submitting your response [Patient consent forms]
  • By submitting this response you are agreeing to our full [Response terms and requirements]

Vertical Tabs

Other responses

Jump to comment:

  • Published on:
    Leukotrienes and familial mediterranean fever
    • R Manna, Prof
    • Other Contributors:
      • "La Regina M, Nucera G, Diaco M"

    Dear Editor,

    Frenkel J et al found an increased urinary leukotriene E4 during febrile attacks in Hyperimmunoglobulinaemia D and periodic fever syndrome (HIDS), but not in children with fever due to viral or bacterial infections. Starting from the well known alteration of the cholesterol metabolism, due to Mevalonate kinase (MVK) deficiency in HIDS and Mevalonic aciduria (MA), they investigated the role of the...

    Show More
    Conflict of Interest:
    None declared.