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Pneumococcal conjugate vaccine and otitis media

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    Up to 50% of acute otitis media is caused by pneumococci. Conjugate vaccines, you would think, should be able to make inroads into this number and the morbidity and economic costs associated with the disease. A trial in Finland (New England Journal of Medicine2001;344:403–9), however, has shown no clear cut reduction in the total number of cases.  A total of 1662 infants were randomised to …

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