OBJECTIVE To investigate the relation between total serum IgE at 0.5–3 and 3–6 years, and the risk of allergic sensitisation and persistent wheezing up to 8 years of age.
METHODS Prospective follow up study of 45 infants with highly recurrent wheezing, no allergic symptoms, and negative skin tests.
RESULTS In the last follow up year, 15 children still suffered from wheezing. Five wheeze-free and four episodically wheezing children had become sensitised. No association was found between early (0.5–3 years) IgE z scores and the recurrence of wheezing during follow up, or atopic sensitisation. IgE z scores at 3–6 years were significantly higher in children with positive skin tests (p = 0.013), but were still not associated with recurrence of wheezing.
CONCLUSIONS In subjects with frequent early wheezing and no signs of atopy, early total serum IgE measurements are not predictive of outcome.
- childhood asthma
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.