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Niflumic acid and cutaneous reactions in children
  1. F Menniti-Ippolitoa,
  2. L Saglioccab,
  3. R Da Casa,
  4. G Saggiomob,
  5. R Di Nardob,
  6. G Traversaa,
  7. the Santobono Study Group for Adverse Drug Reactions in Children
  1. aDepartment of Epidemiology and Biostatistics, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy, bSantobono Hospital, Via Mario Fiore 6, 80129 Naples, Italy
  1. Dr Menniti-Ippolitofmenniti{at}


In a case control study of adverse drug reactions in children, the odds ratio of developing a serious mucocutaneous event among users of niflumic acid, adjusted for concomitant use of all other drugs, was 4.9 (95% CI 1.9 to 12.8). Given the availability of safer analgesics and antipyretics, there is no indication, in our opinion, that requires the prescription of substances which bear an increased risk.

  • adverse drug reactions
  • niflumic acid
  • cutaneous reactions
  • pharmacoepidemiology

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