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Short report
Niflumic acid and cutaneous reactions in children
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  • Published on:
    Niflumic acid and cutaneous reactions in children: a reply

    Dear Editor,

    We saw the letter by Grigoletto and Viola [1], in response to our article [2]and we would like to reply to the specific comments that were put forward. The first remark relates to the possibility that we may have introduced a bias in the choice of the conditions that were selected as controls. The selection of the control group is always a critical aspect in the design of a case-control study. In...

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    Conflict of Interest:
    None declared.
  • Published on:
    Niflumic acid and cutaneous reactions: a controversial association.


    We read the Short Report by Menniti-Ippolito et al[1] with interest. Their conclusions assert that the administration of niflumic acid to paediatric patients increases the risk of mucocutaneous reactions with statistical significance, and thus it would not seem opportune to prescribe this drug given the availability of other safer analgesics and antipyretics. We believe that their results cannot ju...

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    Conflict of Interest:
    None declared.
  • Published on:
    Use of niflumic acid in children
    • Maurizio Bonati, Laboratory for Mother and Child Health
    • Other Contributors:
      • "Antonio Clavenna, Francesca Rocchi, Piero Impicciatore"

    Dear Editor

    The recent report of serious mucocutaneous reactions in fifteen Italian children who took niflumic acid in general practice raises concerns about the rational use of drugs in children everywhere [1]. Niflumic acid (and its beta-morpholinoethyl ester: morniflumate) is a non-steroidal anti-inflammatory drug (NSAID) that has been marketed in Italy since 1981 and also available for use in children in France a...

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    Conflict of Interest:
    None declared.