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Spacers and holding chambers: Not the last word, we hope—a reply
  1. H J ZAR,
  2. M MANN,
  1. Department of Paediatrics and Child Health
  2. Red Cross Children's Hospital
  3. University of Cape Town, South Africa

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Editor,—In his recent letter, Dr Mitchell was concerned that the methodology used in our study did not simulate the release of aerosol from a metered dose inhaler (MDI).1However, as we discussed, the method of aerosol delivery in our study differs from that of a MDI but, because the delivery system was kept constant and the particular spacer varied, a valid comparison of the efficacy of different spacers could be made.2 This delivery system has been previously …

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