Editor,—Seizures in infancy and early childhood responsive to pyridoxine are well recognised but rare. Baxter has recently observed that almost a third of neonatal cases of pyridoxine dependency present with apparent birth asphyxia and/or suspected hypoxic-ischaemic encephalopathy, and recommended that, because of the high proportion of atypical cases, all children with early onset (younger than 3 years old) intractable seizures or status should receive a trial of pyridoxine whatever the suspected cause.1 Following this recommendation can be of …