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Pyridoxine dependent and pyridoxine responsive seizures
  1. D HINDLEY, Consultant Paediatrician
  1. M HUYTON, Associate Specialist
  1. Fairfield General Hospital
  2. Rochdale Old Road
  3. Bury BL9 7TD, UK
  4. The David Lewis Centre
  5. Alderley Edge, Cheshire, UK

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Editor,—Seizures in infancy and early childhood responsive to pyridoxine are well recognised but rare. Baxter has recently observed that almost a third of neonatal cases of pyridoxine dependency present with apparent birth asphyxia and/or suspected hypoxic-ischaemic encephalopathy, and recommended that, because of the high proportion of atypical cases, all children with early onset (younger than 3 years old) intractable seizures or status should receive a trial of pyridoxine whatever the suspected cause.1 Following this recommendation can be of …

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