Editor,—Caffarelli et alcomment on several immunological mechanisms by which gastrointestinal symptoms could occur in asthma.1 They do not comment on whether they excluded cystic fibrosis (CF). This is relevant as there are an increasing number of mild phenotypes of CF presenting as asthma.2 CF could be a unifying diagnosis in the “asthmatic” with gastrointestinal symptoms.

The important clinical message is to consider a …