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Natural history of glutaric aciduria type 1
  1. Metabolic Unit
  2. Great Ormond Street Hospital, London, UK
  3. Biochemistry, Endocrinology, and Metabolism Unit
  4. Institute of Child Health, London, UK

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Editor,—In their retrospective study, Monavari and Naughten (Arch Dis Child2000;82:67–70) suggest that early intensive management can alter the natural history of glutaric aciduria type 1. However, the pathogenesis of this disorder is poorly understood and just what is responsible for the better outcome is …

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