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LHRH analogue and growth hormone did not improve the final height of a patient with juvenile hypothyroidism accompanied by precocious puberty
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Editor,—We report an 11 years 8 months old girl with juvenile hypothyroidism and precocious puberty who failed to respond to thyroxine, growth hormone, and luteinising hormone releasing hormone (LHRH) analogue. The patient was considered to be hypothyroid for about two years before the therapy was started. She had a very low serum thyroxine concentration, a height SD score of −3 SD, and a bone age of 10 years 3 months. Her pubertal development was graded as Tanner stage IV of breasts and Tanner stage II of pubic hair. Her menarche occurred at the age of 10 years 3 months. The enlarged …