Article Text

Download PDFPDF
Protracted neonatal hypertrypsinogenaemia, normal sweat chloride, and cystic fibrosis
  1. C Castellani,
  2. A Tamanini,
  3. G Mastella
  1. Cystic Fibrosis Centre, Ospedale Civile Maggiore, Piazzale Stefani 1, 37126 Verona, Italy
  1. Dr Castellani email: cfc{at}


The cystic fibrosis (CF) clinical spectrum has greatly expanded in the past few years, including atypical forms with low sweat chloride concentrations. Two cases are presented which suggest that children detected by neonatal CF screening whose trypsinogen concentrations are still raised by the second month of age could, despite a negative sweat test, be affected by an atypical CF with fully expressed pulmonary involvement.

  • atypical cystic fibrosis
  • neonatal screening
  • hypertrypsinogenaemia
  • sweat test

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.