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Proteus syndrome and immunodeficiency
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  • Published on: 15 March 2000
    Lymphopenia in lymphatic malformations
    • R Lakshman, Clinical Research Fellow
    • Other Contributors:
      • Adam Finn

    Hodge et al(1) draw our attention to the possible association of hypogammaglobulinemia and global lymphopenia with Proteus syndrome. They suggest that this may be secondary to loss of immunoglobulins and lymphocytes into lymphoedematous tissue. We have seen a similar phenomenon in a child with massive cystic hygroma in the neck. Immunological investigations showed persistent severe lymphopenia with low levels of all lym...

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    Conflict of Interest:
    None declared.