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Controlled trials from history
  1. UK Cochrane Centre
  2. NHS R&D Programme
  3. Summertown Pavillion, Middle Way
  4. Oxford OX2 7LG, UK
  5. email:

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    Editor,—Craft1 is right to point out that steps to control selection bias by alternation or randomisation to treatment groups did not begin with the Dutch trials of paludrine in malaria and the Medical Research Council’s (MRC) first trial …

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