Article Text

Download PDFPDF
Differential avian and human tuberculin skin testing in non-tuberculous mycobacterial infection
  1. A J Daley,
  2. D Isaacs
  1. Department of Immunology and Infectious Diseases, Royal Alexandra Hospital for Children, Westmead, NSW 2145, Australia
  1. Dr A J Daley, Centre for Infectious Diseases and Microbiology Laboratory Services, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, NSW 2145, Australia. email: andrewd{at}icpmr.wsahs.nsw.gov.au

Abstract

OBJECTIVE To determine the sensitivity of differential avian and human delayed-type hypersensitivity skin testing in the diagnosis of non-tuberculous mycobacterial lymphadenitis.

METHOD Retrospective review of all patients with culture proved non-tuberculous mycobacterial lymph node infections who also had differential avian and human skin testing performed over a 10 year period from 1986 to 1996.

RESULTS One hundred and twenty four patients had non-tuberculous mycobacteria isolated from lymph nodes over this period, 59 of whom had differential skin testing performed. The sensitivity of a response of ⩾ 10 mm to the avian precipitin was 58 of 59. No patient had both a negative human and avian Mantoux. The sensitivity of the human Mantoux alone for diagnosing non-tuberculous mycobacterial infection was 81% for a response of ⩾ 5 mm and 66% for ⩾ 10 mm. Ten patients had a 0 human response. Fifty five of the 59 patients had an avian response at least 2 mm greater than the human response.

CONCLUSION The avian Mantoux is a very sensitive method of diagnosing non-tuberculous mycobacterial infection in children. The human Mantoux is not sensitive enough to be used alone as a surrogate to diagnose non-tuberculous mycobacterial infection.

  • non-tuberculous mycobacteria
  • Mantoux
  • lymphadenopathy

Statistics from Altmetric.com

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.