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Urinary excretion of pyridinium crosslinks in healthy 4–10 year olds
  1. Shahid M Husaina,
  2. Zulf Mughalb,
  3. Gwen Williamsc,
  4. Kate Wardb,
  5. Colin S Smithc,
  6. John Duttond,
  7. William D Fraserd
  1. aDepartment of Child Health, St Bartholomew’s and the Royal London School of Medicine and Dentistry, Homerton Hospital, London E9 6SR, UK, bDepartment of Paediatric Medicine, St Mary’s Hospital, Manchester M13 0JH, UK, cInstitute of Child Health, Royal Liverpool Children’s Hospital, Liverpool L12 2AP, UK, dDepartment of Clinical Chemistry, Faculty of Medicine, University of Liverpool, Liverpool L69 3GA, UK
  1. Dr S Husain, Department of Neonatology, Homerton Hospital, Homerton Row, London E9 6SR, UK.

Abstract

Urinary pyridinoline and deoxypyridinoline, pyridinium crosslinks released during breakdown of mature collagen, might serve as useful markers of bone resorption. Before their role can be identified, reference values must be established. In this study, free pyridinoline (f-Pyr), free deoxypyridinoline (f-DPyr), and creatinine (Cr) were measured in first morning void urine samples from 250 girls and 265 boys between the ages of 4 and 10 years. Overall, there was a decrease in f-Pyr:Cr and f-DPyr:Cr ratios with increasing age in both sexes, but there was a wide range of values for individuals of similar ages. Further studies are required to assess whether urinary pyridinium crosslink excretion is sufficiently deranged in conditions affecting bone metabolism for the measurement of these compounds to be of clinical value.

  • pyridinoline
  • deoxypyridinoline
  • bone resorption

https://doi.org/10.1136/adc.80.4.370

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