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The first randomised controlled trial
  1. A W CRAFT

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      The Dutch trials of paludrine in malaria and the MRC’s first trial of streptomycin in pulmonary tuberculosis are usually cited as the first publications of the results of randomised controlled trials (RCT). They were both published in the late 1940s. They indeed are probably the first reports of RCTs with a positive outcome. However, negative trials are equally important …

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