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Raised cerebrospinal fluid glycerol concentration associated with use of dichloroacetate
  1. A A M MORRIS
  1. Department of Child Health
  2. Royal Victoria Infirmary
  3. Newcastle upon Tyne,UK
  4. Institute of Child Health
  5. London, UK
    1. J V LEONARD,
    2. A AYNSLEY-GREEN
    1. Department of Child Health
    2. Royal Victoria Infirmary
    3. Newcastle upon Tyne,UK
    4. Institute of Child Health
    5. London, UK

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      Editor,—Treatment of inborn errors of metabolism often involves the use of chemicals that have not been subjected to rigorous drug trials. Stacpoole et alrecently reviewed the use of dichloroacetate in congenital lactic acidises.l Although dichloroacetate has been used in many patients with acquired problems, the authors could only find data concerning its use in 53 patients with inborn errors. Vigilance …

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