Article Text

Down’s syndrome in infants of diabetic mothers
  1. JÖRG PELZ,
  2. JURGEN KUNZE
  1. Institut fur Humangenetik
  2. Humboldt Universitat zu Berlin
  3. Charité Campus Virchow Klinikum
  4. Augustenburger Platz 1
  5. 13353 Berlin, Germany

    Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    Editor,—In a recent paper Narchi and Kulaylat1 analysed the prevalence (erroneously termed incidence2) of trisomy 21 in children of mothers with diabetes (7/1870) and in non-diabetic mothers (28/20 430) and found it to be significantly higher in the former. All seven cases in the diabetes group occurred in mothers with gestational diabetes.

    The authors concluded, that: (1) Maternal gestational diabetes is an independent risk factor for Down’s syndrome, irrespective of maternal age, as in an analysis of their data stratified by age, all five age groups showed a higher relative risk for Down’s syndrome in diabetic mothers; (2) Down’s syndrome should be added to the list of congenital anomalies known to occur more frequently in infants of diabetic mothers.

    Table 2 in their paper does not fully support their hypothesis. As can be seen from their data, age is a confounding factor for gestational diabetes …

    View Full Text