Article Text

Download PDFPDF
Thrombocytopenic purpura as adverse reaction to recombinant hepatitis B vaccine
  1. F Ronchia,
  2. P Cecchia,
  3. F Falcionia,
  4. A Marsciania,
  5. G Minaka,
  6. G Muratoria,
  7. P L Tazzarib,
  8. S Beverinia
  1. aDivisione Pediatrica—Ospedale Civile di Cattolica (RN), Cattolica (RN), Italy, bServizio di Immunoematologia e Trasfusionale—Policlinico S Orsola, Bologna, Italy
  1. Dr F Ronchi, Divisione Pediatrica Ospedale di Cattolica, Via Beethoven 41—47033 Cattolica (RN), Italy.


Three cases of immune thrombocytopenic purpura after the first dose of recombinant hepatitis B vaccine occurred in infants under 6 months of age. Other possible causes of this condition were excluded. Antiplatelet antibodies were present. A defect in platelet production was excluded in two children. Corticosteroid treatment was effective. Subsequent administration of other vaccines (against polio, diphtheria, and tetanus) did not cause relapse of thrombocytopenia.

  • recombinant hepatitis B vaccine
  • thrombocytopenic purpura
  • antiplatelet antibodies

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.