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Gastric tonometry in septic shock
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  • Published on:
    Monitoring tissue pH vs lactate and ATP degradation products in sepsis

    Dear Editor,

    In rats "impaired microcirculatory alteration in septic shock is more severe than hemorrhagic shock" (1). Endotoxin [which is used to induce septic shock in animal models and when translocating from the gut is thought to contribute to the development of septic shock in the critically ill] increases serum lactate by "inactivation of pyruvate dehydrogenase (PDH), unrelated to changes in tissue PO2" (2)...

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    Conflict of Interest:
    None declared.
  • Published on:
    Tissue pH vs ATP degradation products.

    Dear Editor,

    In rats "impaired microcirculatory alteration in septic shock is more severe than hemorrhagic shock" (1). Endotoxin [which is used to induce septic shock in animal models and when translocating from the gut is thought to contribute to the development of septic shock in the critically ill] increases serum lactate by "inactivation of pyruvate dehydrogenase (PDH), unrelated to changes in tissue PO2" (2)...

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    Conflict of Interest:
    None declared.
  • Published on:
    Hepatic oxygenation for septic shock, and viral cardiomyopathy?

    Dear Editor,

    Oxygen delivery to the liver might be the limiting factor in septic patients in whom there is a risk of cardiac arrest from acute heart failure. That Lillehei was able to prevent irreversible haemorrhagic shock by oxygenating the gut (1) might not have been due to a gut factor, as commonly supposed, but due to the failure of the liver to metabolise and recycle the lactate and other metabolic products of...

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    Conflict of Interest:
    None declared.
  • Published on:
    Irreversible shock, gastric intramucosal pH and energy charge.

    Dear Editor,

    Septic shock is characterised by a hyperdynamic, vasodilated circulation associated with cytolin release and its inhibitory effect upon oxygen uptake and utilisation. Most deaths are late and occur after patients have developed multiple organ dysfunctions. In these cases cardiac arrest is preceded by a declining cardiac output the invariable cause of death. Haemorrhagic shock differs only in that i...

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    Conflict of Interest:
    None declared.