Article Text

Download PDFPDF

Factors involved in the rate of fall of thyroid stimulating hormone in treated hypothyroidism
  1. J Raza,
  2. P C Hindmarsh,
  3. C G D Brook
  1. London Centre for Paediatric Endocrinology, Great Ormond Street Hospital for Children, London WC1N 3JH
  1. Professor Brook.

Abstract

The rate of fall of serum thyroid stimulating hormone (TSH) concentrations in 32 hypothyroid infants (11 boys, 21 girls) was studied after starting treatment with thyroxine to determine whether it was influenced by initial TSH concentration or the cause of the hypothyroidism. Of 27 patients who had isotope scans before treatment was started, 11 (40%) were athyrotic, 10 (38%) had an ectopic gland, and six (22%) probably had dyshormonogenesis. Treatment was started with thyroxine at 100 μg/m2/24 hours at a mean age of 26 days (range 14–45). Serum TSH concentrations remained increased in 26 (81%) at 3 months, 20 (62.5%) at 6 months, and nine (28%) at 1 year and beyond. The mean age for serum TSH to reach the normal range was 0.79 years (range 0.15–2.1 years). Diagnosis (in 27 patients) and initial results (in 32) made no difference to the rate of fall.

  • thyroid stimulating hormone
  • congenital hypothyroidism
  • thyroxine
View Full Text

Statistics from Altmetric.com

Footnotes

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.