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Editor,—Although numerous investigations suggest an immunological process involving a disturbance of the regulatory mechanism for IgA synthesis,1 the aetiology of Henoch-Schönlein purpura are still unresolved.
We report a 4 year old boy who received a liver transplant at the age of 3 years after developing a fulminant liver failure due to intoxication with α-amanitin. After transplantation, immunosuppressive treatment with cyclosporin (Neoral, Sandoz) and prednisone was carried out. During later care the cyclosporin trough serum concentrations always exceeded 100 ng/ml, while simultaneously the dose of corticosteroids was reduced to 1 mg/day. …
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