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Long term follow up of children born to mothers with periconceptional multivitamin supplementation
  1. Department of Human Genetics and Teratology
  2. National Institute of Public Health
  3. WHO Collaborating Centre for the Community Control of Hereditary Diseases
  4. Budapest, Hungary
  1. Dr M Dobó, H-1096 Budapest OKI, Gyáli út 2-6, Hungary

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Editor,—Before recommending periconceptional folic acid-containing multivitamin supplementation universally for the prevention of neural tube defects one would also want to be sure that it was doing no harm. A UK study showed the over-representation of worries and anxiety among children at age 7–10 years born to mothers with periconceptional multivitamin supplementation.1 In our previous study based on a short term postnatal follow up of 3356 infants (mean age 11 months) born to mothers supplemented with multivitamin or placebo-like trace element2 in the periconceptional period, the results of the tests of mental and behavioural development were similar in …

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