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Long term follow up of children born to mothers with periconceptional multivitamin supplementation
  1. MÁRTA DOBÓ,
  2. ANDREW E CZEIZEL
  1. Department of Human Genetics and Teratology
  2. National Institute of Public Health
  3. WHO Collaborating Centre for the Community Control of Hereditary Diseases
  4. Budapest, Hungary
  1. Dr M Dobó, H-1096 Budapest OKI, Gyáli út 2-6, Hungary

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Editor,—Before recommending periconceptional folic acid-containing multivitamin supplementation universally for the prevention of neural tube defects one would also want to be sure that it was doing no harm. A UK study showed the over-representation of worries and anxiety among children at age 7–10 years born to mothers with periconceptional multivitamin supplementation.1 In our previous study based on a short term postnatal follow up of 3356 infants (mean age 11 months) born to mothers supplemented with multivitamin or placebo-like trace element2 in the periconceptional period, the results of the tests of mental and behavioural development were similar in …

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