Article Text
Book review
Gene Therapy. A Primer for Physicians.
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Gene Therapy. A Primer for Physicians. 2nd Ed. By Kenneth W Culver. (Pp 198; hardback.) Mary Ann Liebert, 1996. ISBN 0-913113-25-5 .
By 1995, over 1000 individuals had received experimental gene therapy treatment. The principles are clear—the gene of interest has to be identified, a delivery system developed, and the regulation of the expression of the gene has to be understood—for example our understanding of the control of the insulin and β-globin genes is incomplete and so gene therapy for diabetes and haemoglobinopathies is distant. The best candidates are disorders involving ‘housekeeping’ genes that do not require tight regulation of gene expression to match their function.
Gene transfer can be performed in …