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Graves’ disease associated with exophthalmos, cerebral ventricular dilatation and accelerated growth
  1. Osamu Arisakaa,
  2. Atsuto Hosakaa,
  3. Hajime Araib,
  4. Sachi Fujiwaraa,
  5. Rieko Tadokoroa,
  6. Keijiro Yabutaa
  1. aJuntendo University School of Medicine, Tokyo, Japan: Department of Pediatrics, bDepartment of Neurosurgery
  1. Dr O Arisaka, Department of Pediatrics, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113, Japan.


A report is presented of a girl with Graves’ disease, which was diagnosed at the age of 1.7 years. The mother had no thyroid disease. The patient developed signs of hyperthyroidism shortly before her first birthday, and the most prominent manifestations were accelerated skeletal maturation and linear growth, and dilatation of the brain ventricles. The latter manifestation, which has not been reported previously, was reversible upon normalisation of thyroid function with antithyroid treatment for three years.

  • Graves’ disease
  • reversible ventriculomegaly
  • growth acceleration.

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