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Proinflammatory and anti-inflammatory cytokines in meningococcal disease.
  1. F A Riordan,
  2. O Marzouk,
  3. A P Thomson,
  4. J A Sills,
  5. C A Hart
  1. Institute of Child Health, University of Liverpool.


    Interleukin-10 (IL-10), an anti-inflammatory cytokine, was measured in 131 children with meningococcal disease. IL-10 concentrations were significantly higher in children who died and correlated positively with proinflammatory cytokines. Children who die from meningococcal disease have high IL-10 concentrations, which do not suppress proinflammatory cytokines.

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