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Successful treatment of non-familial haemophagocytic lymphohistiocytosis with interferon and gammaglobulin.
  1. E J Estlin,
  2. R D Palmer,
  3. K P Windebank,
  4. M F Lowry,
  5. A D Pearson
  1. Department of Child Health, Sir James Spence Institute of Child Health, Royal Victoria Infirmary, Newcastle upon Tyne.


    Two cases of non-familial haemophagocytic lymphohistiocytosis (HLH) are presented in which treatment with interferon alfa and gammaglobulin was associated with complete clinical remission. In one case, serological evidence of recent Epstein-Barr virus infection was found. Natural killer cell activity was within normal limits in both children, compatible with a secondary form of HLH. The combination of interferon alfa and intravenous gammaglobulin requires further evaluation in the treatment of non-familial HLH.

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