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Once daily antibiotic regimen in paediatric oncology.
  1. E Bouffet,
  2. C Fuhrmann,
  3. D Frappaz,
  4. D Couillioud,
  5. V Artiges,
  6. C Charra,
  7. D Bouhour,
  8. M Brunat Mentigny
  1. Paediatric Department, Centre L. Bérard, Lyon, France.


    The feasibility and efficacy of a once daily antibiotic regimen were assessed in children with malignant tumours. Over a 44 month period, 296 febrile episodes were treated with a regimen of once daily ceftriaxone-amikacin (and teicoplanin or vancomycin if the patient had a central line). The treatment was successful in 272 (92%) episodes without modification of the antibiotic regimen, and only one patient died of uncontrolled sepsis. A once daily antibiotic regimen is therefore feasible and worthwhile in the treatment of febrile episodes in children with cancer.

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