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Attainment of normal height in severe juvenile hypothyroidism.
  1. K Minamitani,
  2. A Murata,
  3. H Ohnishi,
  4. K Wataki,
  5. T Yasuda,
  6. H Niimi
  1. Department of Paediatrics, Chiba University School of Medicine, Japan.


    Prolonged juvenile hypothyroidism results in a permanent loss in height that is related to the duration of thyroxine deficiency before adequate thyroxine replacement treatment. A 13 year old girl with severe juvenile hypothyroidism was studied prospectively. She had an undetectable serum thyroxine concentration, a height SD score of -6.6 SD, and a bone age of 5.8 years. The enlarged pituitary gland involuted with thyroxine treatment to produce an empty sella. In addition to thyroxine the girl was treated with a gonadotrophin releasing hormone agonist to avoid the progression of puberty for 18 months and with growth hormone to achieve normal adult height.

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      R Stanhope