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Intermittent versus continuous administration of growth hormone treatment.
  1. V Hakeem,
  2. P C Hindmarsh,
  3. C G Brook
  1. Endocrine Unit, Middlesex Hospital, London.


    Growth hormone treatment given by daily injection was compared with growth hormone given for three weeks of every four. All children had received recombinant human growth hormone for two years before randomisation. Growth velocity decreased in both groups in years one and two of the study but the effect was significantly greater in the group receiving intermittent growth hormone.

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