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Fetal anaemia and its relation with increased concentrations of adenosine.
  1. R I Ross Russell,
  2. A Greenough,
  3. H Lagercrantz,
  4. I Dahlin,
  5. K Nicolaides
  1. Department of Child Health, Kings College Hospital, London.


    Adenosine concentrations were measured in umbilical venous blood obtained by cordocentesis from 14 fetuses of 19-34 weeks' gestation. The concentration did not change significantly with gestational age, but anaemic fetuses showed significantly increased concentrations of adenosine and there was a positive association with blood oxygen tension. These findings suggest that the fetus responds to tissue hypoxia by increasing blood adenosine concentrations from at least 19 weeks' gestation.

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