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Thrombolysis with low dose tissue plasminogen activator.
  1. E Doyle,
  2. J Britto,
  3. J Freeman,
  4. F Munro,
  5. N S Morton
  1. Intensive Care Unit, Royal Hospital for Sick Children, Yorkhill, Glasgow.


    Two cases of vena caval thrombosis in infants were successfully treated with low dose (0.01-0.05 mg/kg/hour) local infusions of tissue plasminogen activator after conventional anticoagulant treatment had been unsuccessful. This approach is useful for clots associated with indwelling intravascular catheters, and a low dose infusion of tissue plasminogen activator as a regional application is recommended to achieve clot lysis with minimal systemic effects.

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