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No sensory neuropathy during pyridoxine treatment in homocystinuria.
  1. C Mpofu,
  2. S M Alani,
  3. C Whitehouse,
  4. B Fowler,
  5. J E Wraith
  1. Willink Biochemical Genetics Unit, Royal Manchester Children's Hospital.


    Seventeen patients with cystathionine synthase deficiency homocystinuria were examined clinically and neurophysiologically for evidence of sensory neuropathy. All had received high dose pyridoxine (vitamin B-6) for many years. Absence of neurological disturbance in all cases suggests long term treatment with pyridoxine in the dosages used in homocystinuric patients is not harmful.

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