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Herpes simplex encephalitis with relapse.
  1. M G Pike,
  2. C R Kennedy,
  3. B G Neville,
  4. M Levin
  1. Hospital for Sick Children, London.


    Three children are described in whom herpes simplex encephalitis (HSE) followed a clearly biphasic course. The secondary deterioration may be due to a resurgence of the viral infection and calls into question the adequacy of current treatment regimens for HSE. Alternatively, a postinfectious neuroallergic process may be active in which case immunomodulatory treatment might be more appropriate than further antiviral treatment.

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