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Absence of Y specific DNA sequences in two siblings with 46XX hermaphroditism.
  1. J Raine,
  2. M E Robertson,
  3. S Malcolm,
  4. H Hoey,
  5. D B Grant
  1. Hospital for Sick Children, London.


    We report two siblings with 46XX hermaphroditism in whom we were unable to show the presence of Y specific DNA sequences using the DNA probes Y-190, GMGY-7, pHY2.1, pDP34, and 27a. We conclude that an autosomal or X chromosome gene mutation is the most likely mechanism of inheritance in this family with 46XX hermaphroditism.

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