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Haemophilus influenzae type b disease in the Oxford region.
  1. G Tudor-Williams,
  2. J Frankland,
  3. D Isaacs,
  4. R T Mayon-White,
  5. J A MacFarlane,
  6. M P Slack,
  7. E Anderson,
  8. D G Rees,
  9. E R Moxon
  1. University Department of Paediatrics, John Radcliffe Hospital, Oxford.


    A prospective survey of children in the Oxford region identified 200 cases of systemic Haemophilus influenzae type b disease in the first three and a half years of the study. The annual incidence in children less than 5 years of age was 33.4/100,000. This represents a cumulative incidence of one systemic infection in 600 children before their 5th birthday. The mortality was 5.0%. The risk of H influenzae type b meningitis was one in 850 with a mortality of 5.6%, and substantial morbidity among survivors. From the total live birth rate, about 1300 cases of systemic H influenzae type b disease, over 900 cases of H influenzae type b meningitis, and 65 deaths would be predicted annually in children in the United Kingdom.

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