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Immunoreactive trypsin in Shwachman's syndrome.
  1. J F Dossetor,
  2. H C Spratt,
  3. C J Rolles,
  4. C P Seem,
  5. A F Heeley
  1. Queen Elizabeth Hospital, King's Lynn.


    We studied two infants with Shwachman's syndrome in whom the immunoreactive trypsin concentration was found to be abnormally low. Experience with several hundred assays for immunoreactive trypsin has not shown this low concentration. This finding is probably specific for pancreatic acinar deficiency at this age and strongly suggests Shwachman's syndrome.

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