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Paracetamol suppositories: a comparative study.
  1. S Cullen,
  2. D Kenny,
  3. O C Ward,
  4. K Sabra
  1. Children's Research Centre, Our Lady's Hospital for Sick Children, Dublin.


    Paracetamol suppositories in two different bases were given to children who had fever after operations. Plasma concentrations and the effect on temperature were compared. There was a significant correlation between peak plasma concentrations and maximum drop in temperature. A lipophilic base produced better results than a hydrophilic base.

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