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Severe combined immunodeficiency syndrome, tissue transplant, leukaemia, and Q fever.
  1. M M Loudon,
  2. E N Thompson
  1. Department of Child Health, University of Wales College of Medicine, Cardiff.


    A child born with severe combined immunodeficiency, who was immunoreconstituted by a fetal liver and thymus transplant, developed acute lymphoblastic leukaemia in the donor cell line. During remission she contracted acute Q fever, which gave rise to unexpected complications. Early treatment of the Q fever might have altered the subsequent events and prevented her death.

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