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Acarboxyprothrombin concentration [corrected] after oral prophylactic vitamin K.
  1. R von Kries,
  2. S Kreppel,
  3. A Becker,
  4. R Tangermann,
  5. U Göbel
  1. Department of Paediatrics, University of Düsseldorf, Federal Republic of Germany.


    The effect of prophylaxis with oral vitamin K (1 mg vitamin K1 given with the first feed) on the rate of detection of acarboxyprothrombin (PIVKA II) and factor II clotting concentration [corrected] were analysed. Introducing such prophylaxis reduced the rates of detection of PIVKA II concentration [corrected] on day 5 from 48% to zero. None of the babies given prophylaxis had factor II clotting concentration [corrected] below 40%, compared with 34 of 95 babies not given prophylaxis. This study has important implications in the prophylaxis of both classical and late onset haemorrhagic disease of the newborn.

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