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Prader-Willi syndrome in siblings, due to unbalanced translocation between chromosomes 15 and 22.
  1. F Fernandez,
  2. C Berry,
  3. D Mutton
  1. High Wycombe General Hospital.


    In a family in which the father carried a balanced translocation between chromosomes 15 and 22 two of his children had Prader-Willi syndrome and an unbalanced chromosome complement, having lost the proximal bands from the long arm of chromosome 15. His four other surviving children were normal but carried a balanced translocation.

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