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Valproic acid and immune thrombocytopenia.
  1. R D Barr,
  2. S A Copeland,
  3. M L Stockwell,
  4. N Morris,
  5. J C Kelton


    During the course of a prospective serial study over a period of one year, findings compatible with immune-mediated thrombocytolysis accompanied the administration of valproic acid in about half of 45 children with epilepsy. Thrombocytopenia occurred in 15 and neutropenia in 12 patients, but was transient and self-limiting in each. The association is probably one of cause and effect, and it may reflect the structural similarity between valproic acid and constituents of cell membranes.

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