Article Text

Download PDFPDF
Value of the glucagon test in screening for hepatic glycogen storage disease.
  1. D B Dunger,
  2. J V Leonard


    The fasting glucagon test of 40 patients with hepatic glycogen storage disease (type I, 13 patients; type Ib, 5 patients; type III, 12 patients; type IX (phosphorylase kinase deficiency), 10 patients) has been reviewed. In all patients with types Ib and III the blood glucose level rose less than 1 mmol/1 but in types 1 and IX there was wide variation in response. Blood lactate levels were greater than 2.4 mmol/1 in all patients with type I and Ib 120 minutes after the administration of glucagon but were lower than 2.4 mmol/1 in types III and IX. The value of this test for screening was analysed using several criteria. From the data a simplified scheme for the investigation of patients with suspected hepatic glycogen storage disease is proposed.

    Statistics from

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.